Endocrine Abstracts

Background: A rare cause of ectopic Cushing’s Syndrome (ECS) is pulmonary neuroendocrine neoplasm (NEN) with a broad spectrum of clinical behavior. At the time of diagnosis, pulmonary NENs may present as occult tumors or well-defined round-to-oval lesions in close relationship to the bronchus. Herein, we describe a NEN that developed ECS three years later in a patient followed up for a solitary pulmonary nodule (SPN).Case Presentation: A 56-year-old...

Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis has effects on renal growth and electrolyte regulation. However, data on adverse renal comorbidities such as renal cysts and stones in acromegaly is scarce. The current study aimed to investigate the prevalence of radiologically detectable renal comorbidities and possible related factors in the acromegaly population.Methods: A total of 125 patients with acromegaly (46.4±11.6...

Background: It was previously shown that the levels of several biomarkers increase due to acromegaly disease-related inflammation and that some markers are parallel to the activity of the disease. It was also known that growth differentiation factor 15 (GDF-15) is increased in several cardiovasculary inflammatory and metabolic diseases. The present study aimed to investigate the possible relationship of GDF-15 with acromegaly disease activity by comparing it with healthy indiv...